The prostate normally enlarges in men as they age. However, not all men develop symptoms of BPH.
A derivative of the male hormone testosterone called dihydrotestosterone (DHT), which is concentrated in the prostate, may be associated with growth of the prostate. As men age, their bodies don't produce as much testosterone. However, DHT is still produced. Because the DHT is concentrated in the prostate, this may encourage cell growth.
Another theory talks about the proportions of estrogen and testosterone in a man's body. As men age, there is a higher proportion of estrogen compared to testosterone. Animal studies have suggested that higher amounts of estrogen within the prostate gland may trigger substances that promote prostate cell growth.
It is not known what makes the prostate more or less susceptible to hormonal effects. Age, nationality or a family history of BPH may account for this susceptibility to some extent.
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