NEW YORK (Reuters Health) Jan 17 - Short-term treatment with selegiline transdermal system (STS), a dermally administered monoamine oxidase inhibitor, does not impair sexual function in patients with major depressive disorder, results of a meta-analysis published in the December issue of the Journal of Clinical Psychiatry suggest.
According to Dr. Anita H. Clayton, of the University of Virginia Health System, Charlottesville, and colleagues, product labeling indicates that the incidence of spontaneously reported sexual side effects of antidepressants is relatively low. However, recent studies "using patient-completed or clinician-administered questionnaires have found rates ranging from 22% to 73%."
The researchers examined the impact of STS 6 mg/24 hours on various domains of sexual function in four short-term (6 to 8 weeks), randomized, double-blind, placebo-controlled trials of STS in patients with major depressive disorder (STS, n = 389; placebo, n = 400). A standardized patient-rated questionnaire was used to assess sexual interest, arousal, maintenance of interest, orgasm, and satisfaction.
The patients had a mean age of 42 years, and 62% were female.
Estimates of differences between STS and placebo revealed a nonsignificant trend toward a positive treatment effect of STS on most domains of sexual function, overall.
A significant positive effect was observed for women on the domains of interest, maintaining interest during sex, and satisfaction. No differences between STS and placebo were found for men.
A multivariate regression analysis was conducted to differentiate a direct effect of STS on changes in sexual function from an indirect effect mediated through improvement of depressive symptoms. "Differences between STS and placebo were not significant in this analysis, indicating that STS treatment did not worsen any domain of sexual function in either women or men after controlling for improvement in depression," Dr. Clayton's team reports.
J Clin Psychiatry 2007;68:1860-1866.
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